Can you shoot a 300 savage cartridge from 308 rifle?

No, you cannot safely shoot a .300 Savage cartridge from a .308 rifle. While these two cartridges use bullets of the same diameter, the rim of the .300 Savage cartridge is approximately 0.04 inches (1.02 mm) larger than the rim of a .308 Winchester cartridge. This means that a .300 Savage cartridge will not properly chamber in a .308 rifle, and if fired, it could cause a dangerous situation for the shooter.